期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 25, 页码 7518-7522出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201802889
关键词
biosensing; microneedle; NIR-II imaging; upconversion nanoparticles
资金
- National Key R & D Program of China [2017YFA0207303]
- National Natural Science Foundation of China [21725502, 21701027]
- Key Basic Research Program of Science and Technology Commission of Shanghai Municipality [17JC1400100]
- Natural Science Foundation of Shanghai [18ZR1404600]
- Shanghai Sailing Program [17YF1401000]
Fluorescent bioimaging in the second near-infrared window (NIR-II) can probe deep tissue with minimum auto-fluorescence and tissue scattering. However, current NIR-II fluorophore-related biodetection invivo is only focused on direct disease lesion or organ bioimaging, it is still a challenge to realize NIR-II real-time dynamic biosensing. A new type of Er3+ sensitized upconversion nanoparticles are presented with both excitation (1530 nm) and emission (1180 nm) located in the NIR-II window for invivo biosensing. The microneedle patch sensor for invivo inflammation dynamic detection is developed based on the ratiometric fluorescence by combining the effective NIR-II upconversion emission and H2O2 sensing organic probes under the Fenton catalysis of Fe2+. Owing to the large anti-Stokes shifting, low auto-fluorescence, and tissue scattering of the NIR-II upconversion luminescence, inflammation can be dynamically evaluated invivo at very high resolution (200 x 200 mu m).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据