期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 36, 页码 11764-11769出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201807595
关键词
chemoimmunotherapy; immune checkpoint blockades; immunogenic cell death; immunosuppressive tumors; nanoreactors
资金
- Australian Research Council
- Queensland Government
Immunosuppressive tumors generally exhibit poor response to immune checkpoint blockade based cancer immunotherapy. Rationally designed hybrid nanoreactors are now presented that have integrated functions as Fenton catalysts and glutathione depletion agents for amplifying the immunogenic cell death and activating immune cells. A simple physical mixture of nanoreactors and chemodrugs in combination with immune checkpoint blockades show synergistically and concurrently enhanced chemo-immunotherapy efficacy, inhibiting the growth of both treated primary immunosuppressive tumors and untreated distant tumors. The off-the-shelf strategy uses tumor antigens generated in situ and avoids cargo loading, and is thus a substantial advance in personalized nanomedicine for clinical translation.
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