期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 9, 页码 2334-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201710415
关键词
alkenylboronates; asymmetric catalysis; cyclopropanes; copper; hydroboration
资金
- MINECO [CTQ2014-52769-C03-01-R]
- Junta de Andaluca [P12-FQM-1765]
A novel, highly enantio- and diastereoselective synthesis of 1-boryl-2,3-disubstituted cyclopropanes has been developed by means of the cyclopropanation of alkenylboronates with ethyl diazoacetate in the presence of catalytic amounts of a chiral copper(I) complex. The products can also be directly accessed from alkynes through an operationally simple, sequential hydroboration-cyclopropanation protocol. The resulting enantioenriched 1-boryl-2,3-disubstituted cyclopropanes are versatile synthetic intermediates that undergo further transformations at the carbon-boron bond.
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