期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 19, 页码 5330-5334出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800141
关键词
DNA nanotechnology; DNA origami; membrane deformation; self-assembly; vesicles
资金
- National Institutes of Health (NIH) Director's New Innovator Award [DP2-GM114830]
- NIH [R21-GM109466]
- Yale University
- European Research Council (ERC) under the European Union [669612]
- NIH training grant [T32-GM007499]
- European Research Council (ERC) [669612] Funding Source: European Research Council (ERC)
A major goal of nanotechnology and bioengineering is to build artificial nanomachines capable of generating specific membrane curvatures on demand. Inspired by natural membrane-deforming proteins, we designed DNA-origami curls that polymerize into nanosprings and show their efficacy in vesicle deformation. DNA-coated membrane tubules emerge from spherical vesicles when DNA-origami polymerization or high membrane-surface coverage occurs. Unlike many previous methods, the DNA self-assembly-mediated membrane tubulation eliminates the need for detergents or top-down manipulation. The DNA-origami design and deformation conditions have substantial influence on the tubulation efficiency and tube morphology, underscoring the intricate interplay between lipid bilayers and vesicle-deforming DNA structures.
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