期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 27, 页码 8265-8269出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201804117
关键词
asymmetric catalysis; borylation; chiral amines; difunctionalization; stereodivergent reaction
资金
- JSPS KAKENHI [JP17H06442, JP15K07851]
- JSPS
We report copper(I)-catalyzed enantio- and diastereodivergent borylative coupling of styrenes and imines to produce enantiomerically-enriched gamma-dibranched-boryl amine derivatives. Each of the four possible stereoisomers of the products, derived from the two contiguous stereocenters, was selectively accessible by choosing a proper chiral ligand for the copper catalyst. This method, which combines catalyst-controlled stereodivergency and constitutional divergency derived from the lynchpin motif (i.e., the C-B bond), offers a strategy for addressing the construction of molecular structural diversity concomitant with precise chirality control.
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