期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 28, 页码 8383-8394出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800594
关键词
controlled release; drug delivery; gas therapy; nitric oxide; synergistic therapy
资金
- National Natural Science Foundation of China [51602203]
- Intramural Research Program (IRP) of the NIBIB, NIH
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [ZIAEB000073] Funding Source: NIH RePORTER
Featuring high biocompatibility, the emerging field of gas therapy has attracted extensive attention in the medical and scientific communities. Currently, considerable research has focused on the gasotransmitter nitric oxide (NO) owing to its unparalleled dual roles in directly killing cancer cells at high concentrations and cooperatively sensitizing cancer cells to other treatments for synergistic therapy. Of particular note, recent state-of-the-art studies have turned our attention to the chemical design of various endogenous/exogenous stimuli-responsive NO-releasing nanomedicines and their biomedical applications for on-demand NO-sensitized synergistic cancer therapy, which are discussed in this Minireview. Moreover, the potential challenges regarding NO gas therapy are also described, aiming to advance the development of NO nanomedicines as well as usher in new frontiers in this fertile research area.
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