期刊
ANALYTICAL METHODS
卷 10, 期 16, 页码 1870-1874出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ay00293b
关键词
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资金
- National Natural Science Foundation of China [21205142, 31370104]
- State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University [2017006]
- Research Innovation Program for Graduates of Central South University [2016zzts580, 2017zzts347]
Recently, small molecule and targeted protein interactions have been applied frequently in quantitative detection, with the streptavidin (SA)-biotin model attracting most attention. We address a novel SA detection method based on the terminal protection of a small-molecule-linked DNA probe from degradation by exonuclease I and G-quadruplex-thioflavin T complex fluorescence signal amplification. With the signal amplification strategy, a limit of detection as low as 0.065 nM was reached. The developed strategy provides a new route to a low cost and highly sensitive and selective method of detection of SA in real samples.
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