期刊
ANALYTICAL CHEMISTRY
卷 90, 期 15, 页码 9264-9271出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b01806
关键词
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资金
- National Natural Science Foundation of China [21575100, 21676188]
- Natural Science Foundation of Tianjin [16JCZDJC37100, 18JCZDJC37500]
This work reported the construction of a chiral sensor based on an organic field-effect transistor to probe the subtle change of weak interactions in the chiral discrimination process, with the ability to achieve fast, sensitive, and quantitative real-time chiral analysis for various racemic pairs, where a beta-cyclodextrin (beta-CD) sensitized copper hexadecafluorophthalocyanine (F16CuPc) semiconductive layer was employed as the sensing unit. Physical adsorptive assembly of beta-CD on the semiconductive layer guarantees the impressive field-effect-amplified chiral sensitivity. The enantiomer induced aggregation pattern diversification of the sensing layer resulted in enhanced or weakened surface-dipole interactions to various degrees and hence brought about the drain current fluctuation. A fast and real-time detection of the enantiomer pairs in aqueous solution at 10(-9) M was achieved. This chiral organic field-effect transistor (COFET) afforded reliable ability for quantitative determination of the pure isomer content in enantiomer pairs and was further proven to have great potential for the resolution of real-world pharmaceutical drugs.
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