期刊
NATURE REVIEWS IMMUNOLOGY
卷 16, 期 7, 页码 433-448出版社
NATURE PORTFOLIO
DOI: 10.1038/nri.2016.55
关键词
-
类别
资金
- Aids Fonds [2014014, 2012042, 2010050, 2009024]
- Netherlands Organization for Scientific Research [NGI 40-41009-98-8057, NWO VICI 918.10.619]
- Dutch Burns Foundation [08.109]
- European Research Council [670424]
Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other receptors, such as other CLRs, Toll-like receptors and interferon receptors, to induce signalling pathways that trigger specialized cytokine programmes for polarization of TH cell differentiation. In this Review, we discuss how triggering of the prototypical CLRs leads to distinct pathogen-tailored TH cell responses and how we can harness our expanding knowledge for vaccine design and the treatment of inflammatory and malignant diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据