期刊
ANALYTICAL CHEMISTRY
卷 90, 期 3, 页码 1759-1766出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.7b03675
关键词
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资金
- Natural Science Foundation of China [81373369, 21405127, 21625703, 21707171]
- Hong Kong Research Grants Council [C5031-14E, 5029/13P]
- Science and Technology Planning Project of Guangdong Province, China [2016A040403057]
Replacement of capillary with solid substrates for sample loading and ionization has created many new possibilities for electrospray ionization mass spectrometry (ESI-MS). Surface modification is an attractive strategy to enhance the analytical capability of solid-substrate ESI-MS and allow understanding the relationship between surface activity of solid substrates and analytical properties. In this study, we performed surface modification of wooden tips with hydrophobic (-C-18), basic (-NH2), and acidic (-SO3H) functional groups and applied various sampling methods, i.e., extractive sampling and direct loading, to comprehensively investigate the analytical properties of solid-substrate ESI-MS. Our results showed that, for the direct loading method, analytes with weak interactions with solid-substrate surface could be readily sprayed out for detection. While for the extractive sampling method, analytes strongly retained on solid-substrate surface could be selectively enriched and detected, and a washing step after sample loading could effectively remove unbound components, for reducing interference. Overall, the insights on the effects of surface-analyte interactions on the analytical features obtained in this study could aid the development of surface-modified strategies for enhancing the analytical capability of solid-substrate ESI-MS.
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