期刊
ANALYTICAL BIOCHEMISTRY
卷 552, 期 -, 页码 38-44出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2017.07.006
关键词
Mitochondrial permeability transition pore; Calcium; Osmotic pressure; ATP-synthase; Swelling; C-subunit
资金
- American Heart Association [16GRNT27260229]
- National Institute of Health [GM115570-01A1]
Mitochondrial permeability transition (PT) is a phenomenon of an increase of the inner membrane permeability in response to an excessive matrix calcium accumulation. PTP is caused by the opening of the large weakly selective channel. Molecular composition and regulation of permeability transition pore (PTP) are not well understood. Here we used isolated mitochondria to investigate dependence of PTP activation on the osmotic pressure. We found that in low osmotic strength solution calcium-induced PTP is significantly inhibited. We propose that this effect, is linked to the changes in the curvature of the mitochondrial inner membrane. This interpretation is consistent with the idea about the importance of ATP synthase dimerization in modulation of the PTP activity. (C) 2017 Published by Elsevier Inc.
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