期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 410, 期 24, 页码 6067-6077出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-018-1168-6
关键词
Engineered nanomaterials; Proteomics; Post-translational modifications; Redox proteomics; Thiol; Oxidative stress
资金
- National Institutes of Health [U01ES027292]
- Nanotechnology Health Implications Research (NHIR) [P41GM103493]
- Department of Energy [DE-AC05-76RL0 1830]
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [U01ES027292] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM103493] Funding Source: NIH RePORTER
The widespread use of engineered nanomaterials or nanotechnology makes the characterization of biological responses to nanomaterials an important area of research. The application of omics approaches, such as mass spectrometry-based proteomics, has revealed new insights into the cellular responses of exposure to nanomaterials, including how nanomaterials interact and alter cellular pathways. In addition, exposure to engineered nanomaterials often leads to the generation of reactive oxygen species and cellular oxidative stress, which implicates a redox-dependent regulation of cellular responses under such conditions. In this review, we discuss quantitative proteomics-based approaches, with an emphasis on redox proteomics, as a tool for system-level characterization of the biological responses induced by engineered nanomaterials.
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