期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 410, 期 9, 页码 2395-2402出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-018-0918-9
关键词
Mass spectrometry imaging; Infrared laser; IR-MALDESI; HRAM mass spectrometry
资金
- National Institutes of Health [R01GM087964]
Laser systems are widely used in mass spectrometry as sample probes and ionization sources. Mid-infrared lasers are particularly suitable for analysis of high water content samples such as animal and plant tissues, using water as a resonantly excited sacrificial matrix. Commercially available mid-IR lasers have historically been bulky and expensive due to cooling requirements. This work presents a novel air-cooled miniature mid-IR laser with adjustable burst-mode output and details an evaluation of its performance for mass spectrometry imaging. The miniature laser was found capable of generating sufficient energy for complete ablation of animal tissue in the context of an IR-MALDESI experiment with exogenously added ice matrix, yielding several hundred confident metabolite identifications.
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