期刊
ANALYTICA CHIMICA ACTA
卷 1040, 期 -, 页码 33-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2018.07.032
关键词
Endocrine disrupting compounds; HFRLM; 96-Well plate; Water samples; High-throughput
资金
- Brazilian Government Agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologioco (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
This paper describes a new configuration of the hollow fiber renewal liquid membrane (HFRLM) procedure for the high-throughput determination of the endocrine disrupting compounds 4-nonylphenol, 4-octylphenol, 4-tert-octylphenol, methylparaben, ethylparaben and bisphenol A using a 96-well plate system and high-performance liquid chromatography. In this configuration, cylindrical blades were adapted as a support for polypropylene membranes used as supported liquid membranes in the HFRLM approach. The proposed configuration exhibited important advantages including high-throughput, low solvent and sample consumption, and good analytical performance. The optimized extraction conditions were achieved with the use of a mixture comprised of 50: 50 v/v 1-octanol: hexane as the supported liquid membrane, sample pH 5, extraction solvent 15 mu L (hexane) and extraction time 45 min. The limits of quantification varied from 0.5 mu g L-1 for 4-octylphenol to 15 mg L-1 for methylparaben and ethylparaben and the r(2) ranged from 0.9908 for methylparaben to 0.9992 for 4-tert-octylphenol. HFRLM combined with the use of a 96-well plate provides an environmentally-friendly configuration. It offers good accuracy when applied to analyze water samples, with relative recoveries ranging from 72 to 130%, for 4-octylphenol and 4-nonylphenol, respectively, and precision varying from 1 to 14.3%, for 4-nonylphenol at 1.0 mu gL(-1) and bisphenol A at 8.0 mu g L-1, respectively. (C) 2018 Elsevier B.V. All rights reserved.
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