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On the potential of ion mobility spectrometry coupled to GC pre-separation - A tutorial

期刊

ANALYTICA CHIMICA ACTA
卷 1024, 期 -, 页码 52-64

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2018.02.052

关键词

Ion mobility spectrometry; Pre-separation; Pre-concentration; Ionisation; Sampling; Application

资金

  1. Bundesministerium fur Bildung und Forschung
  2. Ministerium fur Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen
  3. European Union [285446, 217967]

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In this tutorial, we want to demonstrate the significant potential of ion mobility spectrometry (IMS), an analytical technique for identification and quantification of gas-phase compounds, in particular combined to other useful analytical tools. Coupled to gas-chromatographic pre-separation (GC-IMS), selectivity can be improved significantly, thus enabling the analysis of complex, humid mixtures. In-line preconcentration can improve sensitivity down to the ppq(V) range. Furthermore, the use of non-radioactive ionisation sources in the near future could gain acceptance and will avoid legal restrictions. Hence, with suitable and controlled sampling, implementation of appropriate substance and pattern databases and data evaluation software, GC-IMS as rapid, selective and sensitive analytical tool has shown its high potential for many applications in process and quality control, medicine (diagnostics, medication and therapy control), biology, safety and security. In the present tutorial, we want to demonstrate this capacity on behalf of examples from the application fields mentioned above, with particular focus on controlled sampling, pre-concentration and pre-separation as well as on data treatment and interpretation. (C) 2018 Elsevier B.V. All rights reserved.

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