期刊
ANALYST
卷 143, 期 7, 页码 1526-1543出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8an00081f
关键词
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资金
- National Natural Science Foundation of China [21505049]
- Project for Science and Technology Service of the Chinese Academy of Sciences [KFJ-SW-STS-172]
- Hundred Talent Program of the Chinese Academy of Sciences [2010735]
- Natural Science Foundation of China [U1607111, U1501501]
- Zhejiang Provincial Natural Science Foundation of China [R5110230]
- Deutsche Forschungsgemeinschaft (DFG) [WE 5837/1-1]
Graphene-based nanomaterials have been widely utilized to fabricate various biosensors for environmental monitoring, food safety, and biomedical diagnostics. The combination of aptamers with graphene for creating biofunctional nanocomposites improved the sensitivity and selectivity of fabricated biosensors due to the unique molecular recognition and biocompatibility of aptamers. In this review, we highlight recent advances in the design, fabrication, and biomedical sensing application of graphene-based aptasensors within the last five years (2013-current). The typical studies on the biomedical fluorescence, colorimetric, electrochemical, electrochemiluminescence, photoelectrochemical, electronic, and force-based sensing of DNA, proteins, enzymes, small molecules, ions, and others are demonstrated and discussed in detail. More attention is paid to a few key points such as the conjugation of aptamers with graphene materials, the fabrication strategies of sensor architectures, and the importance of aptamers on improving the sensing performances. It is expected that this work will provide preliminary and useful guidance for readers to understand the fabrication of graphene-based biosensors and the corresponding sensing mechanisms in one way, and in another way will be helpful to develop novel high performance aptasensors for biological analysis and detection.
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