期刊
MEDICAL GAS RESEARCH
卷 6, 期 3, 页码 147-153出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/2045-9912.191360
关键词
normobaric hyperoxia; oxygen therapy; stroke; ischemia; neuroprotection; oxidative stress; clinical studies; preclinical studies
资金
- NIGMS NIH HHS [P30 GM103400] Funding Source: Medline
Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据