期刊
NATURE REVIEWS IMMUNOLOGY
卷 16, 期 7, 页码 421-432出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2016.54
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资金
- Wellcome Trust [103930]
- Sir Henry Dale Fellowship - Wellcome Trust
- Sir Henry Dale Fellowship - Royal Society [107609]
- Cancer Research UK [C14303/A17197]
- Wellcome Trust [107609/Z/15/Z] Funding Source: Wellcome Trust
- Cancer Research UK [22257] Funding Source: researchfish
- Wellcome Trust [107609/Z/15/Z] Funding Source: researchfish
Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell, and marked reorganization of both the actin and the microtubule cytoskeletons brings the centrosome up to the plasma membrane to the point of T cell receptor signalling. Secretory granules move towards the centrosome and are delivered to this focal point of secretion. Such centrosomal docking at the plasma membrane also occurs during ciliogenesis; indeed, striking similarities exist between the cytolytic synapse and the primary cilium that throw light on the possible origins of immune synapses.
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