期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 98, 期 6, 页码 1860-1862出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.17-1020
关键词
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资金
- NIH [RO1 NS064905, R01 AI052473, U01 AI088752, R25 TW009338]
- Oswaldo Cruz Foundation
- FOGARTY INTERNATIONAL CENTER [R01TW009504] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI121207] Funding Source: NIH RePORTER
Zika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 +/- 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1-23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.
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