期刊
AMERICAN JOURNAL OF THERAPEUTICS
卷 25, 期 2, 页码 E194-E201出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MJT.0000000000000584
关键词
procyanidin; indoleamine 2; 3-dioxygenase; montmorency tart cherry juice; sleep; tryptophan; kynurenine
资金
- Cherry Marketing Institute
- NORC Center - NIDDK [2P30DK072476]
- National Center for Complementary and Alternative Medicine (NCCAM) [P50AT002776]
- Office of Dietary Supplements (ODS) of the National Institutes of Health
- Department of Plant Biology and Pathology in the School of Environmental and Biological Sciences (SEBS) of Rutgers University
- National Institute of General Medical Sciences of the National Institutes of Health [1 U54 GM104940]
Background:Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire.Study Question:Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia?Study Design:A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout.Measures and Outcomes:Sleep was evaluated by polysomnography and 5 validated questionnaires. Serum indoleamine 2,3-dioxygenase (IDO), the kynurenine-to-tryptophan ratio, and prostaglandin E2 were measured. In vitro, Caco-2 cells were stimulated with interferon-gamma, and the ability of cherry juice procyanidin to inhibit IDO which degrades tryptophan and stimulates inflammation was measured. The content of procyanidin B-2 and other major anthocyanins in cherry juice were determined.Results:Eleven subjects were randomized; 3 with sleep apnea were excluded and referred. The 8 completers with insomnia increased sleep time by 84 minutes on polysomnography (P = 0.0182) and sleep efficiency increased on the Pittsburgh Sleep Quality Index (P = 0.03). Other questionnaires showed no significant differences. The serum kynurenine-to-tryptophan ratio decreased, as did the level of prostaglandin E2 (both P < 0.05). In vitro, cherry juice procyanidin B-2 dose-dependently inhibited IDO.Conclusions:Cherry juice increased sleep time and sleep efficiency. Cherry juice procyanidin B-2 inhibited IDO, increased tryptophan availability, reduced inflammation, and may be partially responsible for improvement in insomnia.
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