期刊
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
卷 59, 期 3, 页码 289-294出版社
AMER THORACIC SOC
DOI: 10.1165/rcmb.2018-0101PS
关键词
acute lung injury; neutrophils; repair; matrix metalloproteinases
资金
- Instituto de Salud Carlos III (Plan Estatal de I+D+I 2013-2016, FEDER funds) [PI16/01614]
- Instituto de Salud Carlos III [CD16/00033]
- Fundacion FINBA
- Fundacion Bancaria Caja de Ahorros de Asturias
Neutrophils are key players in acute lung injury. Once recruited from the circulation, these cells release cytotoxic molecules that lead to tissue disruption, so their blockade has been advocated to prevent lung damage. However, lung injury also occurs during neutropenia and usually involves a very poor outcome. There is emerging evidence that neutrophils not only contribute to that early damage but also orchestrate later repair. Neutrophils promote epithelial proliferation and are a source of proteases, which are required for the processing of the collagen scar and facilitation of cell migration. This article reviews the effects of neutrophils in repair after acute lung injury, focusing on their role as biovectors for proteases and other molecules involved in tissue remodeling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据