期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 79, 期 3, 页码 -出版社
WILEY
DOI: 10.1111/aji.12817
关键词
endometriosis; hematopoietic stem cell; implantation; uterine natural killer cell
资金
- Health Research Board [HRA/POR/2012/37]
- Health Research Board (HRB) [HRA-POR-2012-37] Funding Source: Health Research Board (HRB)
Problem: Uterine natural killer (uNK) cells play a critical role early in gestation. As we previously identified altered uNK cell development in endometriosis-associated infertility, we herein sought to characterize natural killer (NK) cell profiles in endometriosis that may predict embryo implantation. Method of study: Study participants had a surgical diagnosis of endometriosis-associated infertility. Endometrial tissue and peripheral blood were obtained from 58 women. Thirty-three patients underwent artificial reproductive technology (IVF, ICSI, or IUI) within a mean of 9.5 months of surgery. NK and hematopoietic progenitor cells from endometrium and blood were analyzed by flow cytometry. Successful implantation was defined as a positive pregnancy test. Results: In successful implantation, populations of endometrial CD34(+) hematopoietic stem cells were higher (3.97% vs 0.69%; P < .0004), and coexpression of NK cell marker CD56 was increased (81.1% vs 60.9%; P < .034) compared with patients who had failed implantation. In contrast, levels of blood NK progenitors were similar in both groups. Conclusion: Our study revealed that uterine NK progenitor cell populations are markedly different in patients with endometriosis who proceed to successful or failed embryo implantation and may define a novel predictor of implantation success. Our findings also highlight the fundamental differences inherent in NK cell repertoires between blood and uterine compartments.
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