期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 314, 期 2, 页码 E165-E173出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00266.2017
关键词
hyperinsulinemic-euglycemic clamp; insulin resistance; magnetic resonance spectroscopy
资金
- Dutch Diabetes Research Foundation [2009.60.003]
- Helmholtz Alliance with Universities (Imaging and Curing Environmental Metabolic Diseases)
- German Research Foundation (DFG) [SFB 1116]
- Schmutzler-Stiftung
Exercise training reduces intrahepatic lipid (IHL) content in people with elevated liver fat content. It is unclear, however, whether exercise training reduces IHL content in people with normal liver fat content. Here, we measured the effect of exercise training on IHL content in people with and people without nonalcohol fatty liver. We further measured changes in insulin sensitivity and hepatic energy metabolism. Eleven males with nonalcoholic fatty liver (NAFL) and 11 body mass index-matched individuals without nonalcoholic fatty liver (CON) completed a 12-wk supervised exercise training program. IHL content (proton magnetic resonance spectroscopy), maximal oxidative capacity (<(V)over dot>O(2)max, spiroergometry), total muscle strength, body composition, insulin sensitivity (hyperinsulinemic-euglycemic clamp), hepatic ATP-to-total phosphorus ratio, and the hepatic phosphomonoester-to-phosphodiester (PME/PDE) ratio (phosphorus magnetic resonance spectroscopy) were determined. IHL content reduced with exercise training (P = 0.014) in the whole study population. The relative reduction in IHL content was comparable in NAFL (-34.5 +/- 54.0%) and CON (-28.3 +/- 60.1%) individuals (P = 0.800). <(V)over dot>O(2)max (P < 0.001), total muscle strength (P < 0.001), and skeletal muscle insulin sensitivity (P = 0.004) increased, whereas adipose tissue (P = 0.246) and hepatic (P = 0.086) insulin sensitivity did not increase significantly. Hepatic ATP-to-total phosphorus ratio (P = 0.987) and PME/PDE ratio (P = 0.792) did not change. Changes in IHL content correlated with changes in body weight (r = 0.451, P = 0.035) and changes in hepatic PME/PDE ratio (r = 0.569, P = 0.019). In conclusion, exercise training reduced intrahepatic lipid content in people with nonalcoholic fatty liver and in people with normal intrahepatic lipid content, and the percent reduction in intrahepatic lipid content was similar in both groups.
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