期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 315, 期 1, 页码 C80-C90出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00042.2018
关键词
Drp1 modulation; dynamin-related protein 1; mitochondrial fission and fusion; mitophagy
资金
- American Heart Association National Scientist Development Grant [09SDG2260957]
- National Institutes of Health National Heart, Lung, and Blood Institute [R01 HL-105932, R56 HL-105932]
- Joy McCann Culverhouse endowment
The constant physiological flux of mitochondrial fission and fusion is inextricably tied to the maintenance of cellular bioenergetics and the fluidity of mitochondrial networks. Yet, the intricacies of this dynamic duo remain unclear in diseases that encompass mitochondrial dysregulation. Particularly, the role of the GTPase fission protein dynamin-related protein 1 (Drp1) is of profound interest. Studies have identified that Drp1 participates in complex signaling pathways, suggesting that the function of mitochondria in pathophysiology may extend far beyond energetics alone. Research indicates that, in stressed conditions, Drpl translocation to the mitochondria leads to elevated fragmentation and mitophagy: however, despite this, there is limited knowledge about the mechanistic regulation of Drp1 in disease conditions. This review highlights literature about fission, fusion, and, more importantly, discusses Drpl in cardiac, neural, carcinogenic, renal, and pulmonary diseases. The therapeutic desirability for further research into its contribution to diseases that involve mitochondrial dysregulation is also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据