期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 35, 期 13, 页码 1319-1325出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0038-1653946
关键词
nonsteroidal anti-inflammatory drugs; premature; neonate; hemodynamically significant patent ductus arteriosus; paracetamol; ibuprofen; echocardiography
Objective The objective of this study was to compare the closure rate of hemodynamically significant patent ductus arteriosus (hsPDA) of intravenous ibuprofen+paracetamol (acetaminophen) versus ibuprofen+placebo, in preterm infants of 24 to 31 (6/7) weeks postmenstrual age. Study Design This is a single-center, double-blind, randomized controlled pilot study. Infants were assigned for treatment with either intravenous ibuprofen+paracetamol ( n =12) or ibuprofen+placebo ( n =12). Results There was no statistical difference in baseline characteristics of the two groups. Echocardiography parameters were comparable before treatment in both groups. There was a trend toward higher hsPDA closure rate in the paracetamol group in comparison to the placebo group (83 vs. 42%, p =0.08). No adverse effects, clinical or laboratory, were associated with adding paracetamol. Conclusion Our pilot study was unable to detect a beneficial effect by adding intravenous paracetamol to ibuprofen for the treatment of hsPDA. Larger prospective studies are needed to explore the positive tendency suggested by our results and to assure safety.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据