期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms17060907
关键词
protein-protein interaction network; reconstruction technique; interactome; proteome
资金
- National High-Tech Research and Development Program of China (863 programs) [2012AA10A401, 2012AA092205]
- Grants of the Major State Basic Research Development Program of China (973 programs) [2012CB114405]
- National Natural Science Foundation of China [21106095]
- National Key Technology R D Program [2011BAD13B07, 2011BAD13B04]
- Tianjin Research Program of Application Foundation and Advanced Technology [15JCYBJC30700]
- Project of introducing one thousand high level talents in three years [5KQM110003]
- Foundation of Introducing Talents to Tianjin Normal University [5RL123]
- Academic innovation promotion project of Tianjin Normal University for young teachers [52XC1403]
- 131 Innovative Talents cultivation of Tianjin [ZX110170]
The protein-protein interaction network (PIN) is a useful tool for systematic investigation of the complex biological activities in the cell. With the increasing interests on the proteome-wide interaction networks, PINs have been reconstructed for many species, including virus, bacteria, plants, animals, and humans. With the development of biological techniques, the reconstruction methods of PIN are further improved. PIN has gradually penetrated many fields in biological research. In this work we systematically reviewed the development of PIN in the past fifteen years, with respect to its reconstruction and application of function annotation, subsystem investigation, evolution analysis, hub protein analysis, and regulation mechanism analysis. Due to the significant role of PIN in the in-depth exploration of biological process mechanisms, PIN will be preferred by more and more researchers for the systematic study of the protein systems in various kinds of organisms.
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