期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms17060909
关键词
miRNAs; let-7 family; papillary thyroid cancer; carcinogenesis
资金
- Medical University of Lodz [503/0-079-02/503-01-001]
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC.
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