期刊
EXPERIMENTAL NEUROLOGY
卷 274, 期 -, 页码 134-144出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2015.09.010
关键词
Hyaluronan; Proteoglycan; Link protein; Perineuronal net; Plasticity; Node of Ranvier; Saltatory conduction
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [24110509, 26110713]
- Grants-in-Aid for Scientific Research [26110713, 24110509] Funding Source: KAKEN
The hyaluronan and proteoglycanbinding link protein (Hapin) is a key molecule in the formation and control of hyaluronan-based condensed perineuronal matrix in the adult brain. This review summarizes the recent advances in understanding the role of Hapins in the formation and control of two distinct types of perineuronal matrices, one for classical PNN and the other for the specialized extracellular matrix (ECM) at the node of Ranvier in the central nervous system (CNS). We introduce the structural components of each ECM organization including the basic concept of supramolecular structure named HLT model. We furthermore summarize the developmental and physiological role of perineuronal ECMs from the studies of Hapins and related molecules. Finally, we also discuss the potential mechanism modulating PNNs in the adult CNS. This layer of organized matrices may exert a direct effect via core protein or sugar moiety from the structure or by acting as a binding site for biologically active molecules, which are important for neuronal plasticity and saltatory conduction. (C) 2015 Elsevier Inc. All rights reserved.
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