期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms17050603
关键词
antimicrobial peptides; antibiotic resistance; applications; swine; poultry
资金
- 111 Project [B16044]
- Special Fund for Agro-scientific Research in the Public Interest [201403047]
- China National Scientific and Technological Supporting Plan [2011BAD26B02]
Over the last decade, the rapid emergence of multidrug-resistant pathogens has become a global concern, which has prompted the search for alternative antibacterial agents for use in food animals. Antimicrobial peptides (AMPs), produced by bacteria, insects, amphibians and mammals, as well as by chemical synthesis, are possible candidates for the design of new antimicrobial agents because of their natural antimicrobial properties and a low propensity for development of resistance by microorganisms. This manuscript reviews the current knowledge of the basic biology of AMPs and their applications in non-ruminant nutrition. Antimicrobial peptides not only have broad-spectrum activity against bacteria, fungi, and viruses but also have the ability to bypass the common resistance mechanisms that are placing standard antibiotics in jeopardy. In addition, AMPs have beneficial effects on growth performance, nutrient digestibility, intestinal morphology and gut microbiota in pigs and broilers. Therefore, AMPs have good potential as suitable alternatives to conventional antibiotics used in swine and poultry industries.
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