期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 187, 期 11, 页码 2265-2278出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwy139
关键词
asthma; cohort studies; COPD; harmonization; spirometry
资金
- National Institutes of Health
- National Heart, Lung, and Blood Institute [K23-HL-130627, R21-HL-129924, R21-HL121457, HHSN268201700001I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I, HHSN2682017000021, HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C]
- Intramural Research Program of the National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- National Institute on Aging [R01AG023629, N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG028050]
- National Institute of Nursing Research [R01-NR012459]
- National Institute for Minority Health and Health Disparities [HHSN268201300049C, HHSN268201300050C, HHSN268201300048C, HHSN268201300046C, HHSN268201300047C]
- US Environmental Protection Agency [RD831697]
- Intramural Research Program of the NIH, National Institute of Environmental Health Sciences
- National Institute on Minority Health and Health Disparities
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- NIH Institution-Office of Dietary Supplements
- [HHSN268201300029C]
- [HHSN268200900041C]
- [HHSN268201200036C]
- [HHSN268200800007C]
- [N01HC55222]
- [N01HC85079]
- [N01HC85080]
- [N01HC85081]
- [N01HC85082]
- [N01HC85083]
- [N01HC85086]
- [U01HL080295]
- [N01-HC-25195]
Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respiratory data from US general population-based cohorts. Data were obtained from prospective cohorts that performed prebronchodilator spirometry and were harmonized following 2005 ATS/ERS standards. In cohorts conducting follow-up for noncardiovascular events, CLRD events were defined as hospitalizations/deaths adjudicated as CLRD-related or assigned relevant administrative codes. Coding and variable names were applied uniformly. The pooled sample included 65,251 adults in 9 cohorts followed-up for CLRD-related mortality over 653,380 person-years during 1983-2016. Average baseline age was 52 years; 56% were female; 49% were never-smokers; and racial/ethnic composition was 44% white, 22% black, 28% Hispanic/Latino, and 5% American Indian. Over 96% had complete data on smoking, clinical CLRD diagnoses, and dyspnea. After excluding invalid spirometry examinations (13%), there were 105,696 valid examinations (median, 2 per participant). Of 29,351 participants followed for CLRD hospitalizations, median follow-up was 14 years; only 5% were lost to follow-up at 10 years. The NHLBI Pooled Cohorts Study provides a harmonization standard applied to a large, US population-based sample that may be used to advance epidemiologic research on CLRD.
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