期刊
JOURNAL OF PHARMACEUTICAL ANALYSIS
卷 6, 期 4, 页码 235-241出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpha.2016.03.003
关键词
Doxorubicin hydrochloride; Graphene quantum dot; Nanotechnology; Electrochemical sensor
资金
- Hematology-Oncology Research Center, Tabriz University of Medical Sciences [93/5]
Low toxic graphene quantum dot (GQD) was synthesized by pyrolyzing citric acid in alkaline solution and characterized by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), atomic force microscopy (AFM), spectrofluorimetery and dynamic light scattering (DLS) techniques. GQD was used for electrode modification and electro-oxidation of doxorubicin (DOX) at low potential. A substantial decrease in the overvoltage (-0.56 V) of the DOX oxidation reaction (compared to ordinary electrodes) was observed using GQD as coating of glassy carbon electrode (GCE). Differential pulse voltammetry was used to evaluate the analytical performance of DOX in the presence of phosphate buffer solution (pH 4.0) and good limit of detection was obtained by the proposed sensor. Such ability of GQD to promote the DOX electron-transfer reaction suggests great promise for its application as an electrochemical sensor. (C) 2016 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据