期刊
PEDIATRIC OBESITY
卷 11, 期 4, 页码 251-257出版社
WILEY
DOI: 10.1111/ijpo.12053
关键词
Insulin resistance; intima-media thickness; intra-hepatic fat; SGA
类别
资金
- Miguel Servet Fund from Carlos III National Institute of Health, Spain
- Clinical Research Council of the Leuven University Hospitals
- Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III
- Fondo Europeo de Desarrollo Regional (FEDER), Madrid, Spain [PI08/0443, PI11/02403]
- Pfizer [WI176617]
BackgroundInfants born small-for-gestational-age (SGA) who develop post-natal weight catch-up are at risk for insulin resistance, central adiposity and cardiovascular disease in later life, even in the absence of overweight. ObjectiveIn young (age 3-6 years) non-obese SGA children, we assessed arterial health (as judged by intima-media thickness [IMT]) and abdominal fat distribution (subcutaneous, visceral, preperitoneal and hepatic components by magnetic resonance imaging [MRI] and/or ultrasound [US]) besides a selection of endocrine markers. MethodsComparisons of measures in SGA (n=27) vs. appropriate-for-GA (AGA) children (n=19) of similar height, weight and body mass index. Longitudinal outcomes (age 3-6 years) were carotid IMT (cIMT); fasting glucose, circulating insulin, IGF-I and high-molecular-weight (HMW) adiponectin; abdominal fat partitioning by US. Cross-sectional outcomes (age 6 years) were aortic IMT (aIMT) and abdominal fat partitioning by MRI. ResultsAt 3 and 6 years, cIMT and IGF-I results were higher and HMW adiponectin lower in SGA than AGA children; at 6 years, SGA subjects had also a thicker aIMT and more pre-peritoneal and hepatic fat, and were less insulin sensitive (all P values between <0.05 and <0.0001). cIMT correlated positively with pre-peritoneal fat, particularly at 6 years. Post-SGA status and weight gain in early childhood (between 3 and 6 years) were independent predictors of cIMT at 6 years, explaining 48 % of its variance. ConclusionSGA children aged 3-6 years were found to have a thicker intima- media and more pre-peritoneal and hepatic fat than AGA children of comparable size.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据