期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 108, 期 2, 页码 371-380出版社
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/nqy102
关键词
polyamines; spermidine; life span; cancer; vascular disease
资金
- Federal Ministry for Transport, Innovation and Technology (BMVIT) [843536]
- Federal Ministry of Science, Research and Economy (BMWFW) [843536]
- Wirtschaftsagentur Wien [843536]
- Standortagentur Tirol [843536]
- Erwin Schrodinger Fellowship (Austrian Science Fund) [J3679-B13]
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- European Research Council (ERC)
- LabEx Immuno-Oncology
- Paris Alliance of Cancer Research Institutes (PACRI)
- Austrian Science Fund [P23490-B20, P29262, P24381, P 29203, P 27893]
- Austrian Science Fund (SFB Lipotox)
- BMWFW
- BioTechMed-Graz flagship project EPIAge
- Austrian Programme for advanced Research and Technology (APART) fellowship of the Austrian Academy of Sciences
- Austrian Science Fund (FWF) [P29262, P27893] Funding Source: Austrian Science Fund (FWF)
Background: Spermidine administration is linked to increased survival in several animal models. Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans. Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.9% of whom were male. Diet was assessed by repeated dietitian-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. During follow-up between 1995 and 2015, 341 deaths occurred. Results: All-cause mortality (deaths per 1000 person-years) decreased across thirds of increasing spermidine intake from 40.5 (95% CI: 36.1, 44.7) to 23.7 (95% CI: 20.0, 27.0) and 15.1 (95% CI: 12.6, 17.8), corresponding to an age-, sex-and caloric intake-adjusted 20-y cumulative mortality incidence of 0.48 (95% CI: 0.45, 0.51), 0.41 (95% CI: 0.38, 0.45), and 0.38 (95% CI: 0.34, 0.41), respectively. The age-, sex-and caloric ratio-adjusted HR for all-cause death per 1-SD higher spermidine intake was 0.74 (95% CI: 0.66, 0.83; P < 0.001). Further adjustment for lifestyle factors, established predictors of mortality, and other dietary features yielded an HR of 0.76 (95% CI: 0.67, 0.86; P < 0.001). The association was consistent in subgroups, robust against unmeasured confounding, and independently validated in the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) Study (age-, sex-, and caloric ratioadjusted HR per 1-SD higher spermidine intake: 0.71; 95% CI: 0.53, 0.95; P = 0.019). The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7-y (95% CI: 3.6, 8.1 y) younger age. Conclusion: Our findings lend epidemiologic support to the concept that nutrition rich in spermidine is linked to increased survival in humans.
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