期刊
AMERICAN JOURNAL OF CHINESE MEDICINE
卷 46, 期 5, 页码 997-1019出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X18500520
关键词
Manual Acupuncture; Complete Freund's Adjuvant-induced Arthritis; Analgesia; Immune Network Regulation; Cell-Cell Communication Networks
资金
- National Natural Science Foundation of China (NSFC) [81330088, 81603677]
- Natural Science Foundation of Tianjin [16JCYBJC43500]
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory and debilitating disease that involves the systemic imbalance of the immune network. Previous studies have shown that acupuncture can help treat RA. However, its specific mechanisms are not fully understood. Thus, the present study was designed to clarify the mechanisms of acupuncture acted on RA via immune network modulation using complete Freund's adjuvant (CFA)-induced arthritic rats. Results revealed that manual acupuncture (MA) could alleviate the inflammation and pain of infected joints. Moreover, MA could effectively stimulate the innate immune cytokines (IL-1 alpha, IL-1 beta, IL-6, IL-7, IL-18, TNF-alpha) and adaptive immunity cytokines (IL-2, IL-12, IFN-gamma, IL-4, IL-5, IL-10, IL-13, IL-17) as the main part of the immune response and repaired damage of RA. These complex immunomodulatory processes were analyzed quantitatively by cell-cell communication (CCC) networks. The CCC networks demonstrated that the immune networks were enhanced with the development of RA, while MA enhanced the immune networks in the early stage to act on RA and promoted the immune-network to a normal level at the late stage. Moreover, we found that monocyte/macrophage and endothelial cells were the key cells of innate immunity and body cells; T(H)1, T(H)2 and B cells were the key cells of adaptive immunity, which were also the main target cells for MA regulation.
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