期刊
CHEMCATCHEM
卷 8, 期 12, 页码 2023-2026出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201600384
关键词
amines; asymmetric synthesis; biocatalysis; imine reductase; reductive amination
Biocatalysis employing imine reductases is a promising approach for the one-step generation of chiral amines from ketones. The enzymes reported for this process suffer from low activity and moderate stereoselectivity. We identified a set of enzymes that facilitate this reaction with high to quantitative conversions from a library of 28 imine reductases. This enabled the conversion of ketones with ammonia, methylamine, or butylamine into the corresponding amines. Most importantly, we performed preparative (>100mg) scale syntheses of amines such as (1S,3R)-N,3-dimethylcyclohexylamine and (R)-N-methyl-2-aminohexane with excellent stereochemical purities (98%de, 96%ee) in good yields.
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