期刊
ALZHEIMERS & DEMENTIA
卷 14, 期 6, 页码 751-763出版社
WILEY
DOI: 10.1016/j.jalz.2017.12.008
关键词
Neurofilament light; Cerebrospinal fluid; Neurodegenerative dementias; Prion diseases; Alzheimer's disease; Dementia with Lewy bodies; Parkinson's disease dementia; Vascular dementia; Frontotemporal dementia
资金
- Spanish Ministry of Health-Instituto Carlos III [CP16/00041]
- IKYDA Greek-German collaboration project [57260006]
- Robert Koch Institute through funds from Federal Ministry of Health [1369-341]
- Spanish Ministry of Health
- Instituto Carlos III [FIS PI11/00968, FIS PI14/00757]
- CIBERNED project BESAD-P
- Red Nacional de priones [AGL2015-71764-REDT-MINECO]
- Dorothea Schlozer Scholarship (Georg August University-Gottingen)
- [FIS PI16/00235]
Introduction: Neurofilament light (NFL) levels in the cerebrospinal fluid are increased in several neurodegenerative dementias. However, their diagnostic accuracy in the differential diagnostic context is unknown. Methods: Cerebrospinal fluid NFL levels were quantified in nonprimarily neurodegenerative neurological and psychiatric diseases (n = 122), mild cognitive impairment (n = 48), Alzheimer's disease (n = 108), dementia with Lewy bodies/Parkinson's disease dementia (n = 53), vascular dementia (n = 46), frontotemporal dementia (n = 41), sporadic Creutzfeldt-Jakob disease (sCJD, n = 132), and genetic prion diseases (n = 182). Results: The highest NFL levels were detected in sCJD, followed by vascular dementia, frontotemporal dementia, dementia with Lewy bodies/Parkinson's disease dementia, Alzheimer's disease, and mild cognitive impairment. In sCJD, NFL levels correlated with cerebrospinal fluid tau and disease duration. NFL levels were able to differentiate sCJD from nonprimarily neurodegenerative neurolog-ical and psychiatric diseases (area under the curve = 0.99, 95% confidence interval: 0.99-1) and from the other diagnostic groups showing cognitive impairment/dementia of a non-CJD etiology (area under the curve = 0.90, 95% confidence interval: 0.87-0.92). Compared to nonprimarily neurodegenerative neurological and psychiatric diseases, NFL was also elevated in genetic prion diseases associated with the E200K, V210I, P102L, and D178N prion protein gene mutations. Discussion: Increased NFL levels are a common feature in neurodegenerative dementias. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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