期刊
ALZHEIMERS & DEMENTIA
卷 14, 期 11, 页码 1493-1504出版社
WILEY
DOI: 10.1016/j.jalz.2018.01.007
关键词
Coronary heart disease; Myocardial infarction; Heart failure; Dementia; Alzheimer's disease
资金
- Janssen Prevention Center
- Dutch Alzheimer Foundation [WE.15-2016-02]
Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07-1.50]), albeit with considerable heterogeneity across studies (I-2 = 580%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19-2.13]) with moderate heterogeneity (I-2 = 59%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06-1.49], nine studies; and HF, RR 1.80 [1.41-2.31], four studies) and highly consistent (I-2 = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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