期刊
ALZHEIMERS & DEMENTIA
卷 14, 期 4, 页码 514-519出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.11.013
关键词
Alzheimer's disease; ADNI; Mitochondrial genetics; Whole mitochondrial genomes; Next-generation sequencing
资金
- Alzheimer's Disease Neuroimaging Initiative (ADNI) [U01 AG024904]
- DOD ADNI [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- Euroimmun
- F. Hoffmann- La Roche Ltd
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- NIH [R01AG042611, RF1AG054052, U01AG 024904, P30AG010133, R01AG019771, R01LM011360, U01HG006500, U19 HD077671, R01HG02213, R01AG047866, U01AG24904]
- Fulton Supercomputing Lab at Brigham Young University
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [U19HD077671] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG006500, R01HG002213] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG024904, R01AG042611, P30AG010133, R01AG019771, RF1AG047866, U24AG021886, RF1AG054052] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [R01LM011360] Funding Source: NIH RePORTER
Introduction: Mitochondrial genetics are an important but largely neglected area of research in Alzheimer's disease. A major impediment is the lack of data sets. Methods: We used an innovative, rigorous approach, combining several existing tools with our own, to accurately assemble and call variants in 809 whole mitochondrial genomes. Results: To help address this impediment, we prepared a data set that consists of 809 complete and annotated mitochondrial genomes with samples from the Alzheimer's Disease Neuroimaging Initiative. These whole mitochondrial genomes include rich phenotyping, such as clinical, fluid biomarker, and imaging data, all of which is available through the Alzheimer's Disease Neuroimaging Initiative website. Genomes are cleaned, annotated, and prepared for analysis. Discussion: These data provide an important resource for investigating the impact of mitochondrial genetic variation on risk for Alzheimer's disease and other phenotypes that have been measured in the Alzheimer's Disease Neuroimaging Initiative samples. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
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