期刊
ALZHEIMERS & DEMENTIA
卷 14, 期 2, 页码 167-177出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.07.757
关键词
Lipids; Cognition; Dementia; Epidemiology; Cohort; Longitudinal; Cognitive decline; Cognitive change; Cholesterol
资金
- National Institute of Aging [T32 AG027668]
- National Heart, Lung, and Blood Institute [HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C]
- [U01 HL096812]
- [HL096814]
- [HL096899]
- [HL096902]
- [HL096917]
- [R01-HL70825]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL096902, U01HL096812, R01HL070825, U01HL096917, U01HL096899, T32HL007024, U01HL096814] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [T32AG027668] Funding Source: NIH RePORTER
Introduction: Existing studies predominantly consider the association of late-life lipid levels and subsequent cognitive change. However, midlife rather than late-life risk factors are often most relevant to cognitive health. Methods: We quantified the association between measured serum lipids in midlife and subsequent 20-year change in performance on three cognitive tests in 13,997 participants of the Atherosclerosis Risk in Communities study. Results: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides were associated with greater 20-year decline on a test of executive function, sustained attention, and processing speed. Higher total cholesterol and triglycerides were also associated with greater 20-year decline in memory scores and a measure summarizing performance on all three tests. High-density lipoprotein cholesterol was not associated with cognitive change. Results were materially unchanged in sensitivity analyses addressing informative missingness. Discussion: Elevated total cholesterol, low-density lipoprotein cholesterol, and triglycerides in midlife were associated with greater 20-year cognitive decline. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
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