期刊
ALZHEIMERS & DEMENTIA
卷 14, 期 2, 页码 187-194出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2017.07.756
关键词
Everyday cognition; Activity monitoring; Longitudinal; Aging; Computer use; Preclinical AD; Older adults; In-home technology; Ecological validity
资金
- Alzheimer's Association [NIRG-15-362233]
- National Institutes of Health [AG024978, AG024059, AG023477, P30AG008017, AG042191]
- NATIONAL INSTITUTE ON AGING [P30AG024978, P30AG008017, R01AG024059, U2CAG054397, R01AG042191] Funding Source: NIH RePORTER
Introduction: Subtle changes in instrumental activities of daily living often accompany the onset of mild cognitive impairment (MCI) but are difficult to measure using conventional tests. Methods: Weekly online survey metadata metrics, annual neuropsychological tests, and an instrumental activity of daily living questionnaire were examined in 110 healthy older adults with intact cognition (mean age = 85 years) followed up for up to 3.6 years; 29 transitioned to MCI during study follow-up. Results: In the baseline period, incident MCI participants completed their weekly surveys 1.4 hours later in the day than stable cognitively intact participants, P = .03, d = 0.47. Significant associations were found between earlier survey start time of day and higher memory (r = -0.34; P < .001) and visuospatial test scores (r = -0.37; P < .0001). Longitudinally, incident MCI participants showed an increase in survey completion time by 3 seconds per month for more than the year before diagnosis compared with stable cognitively intact participants (beta = 0.12, SE = 0.04, t = 2.8; P = .006). Discussion: Weekly online survey metadata allowed for detection of changes in everyday cognition before transition to MCI. Published by Elsevier Inc.
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