期刊
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
卷 4, 期 -, 页码 1-18出版社
SPRINGER
DOI: 10.1186/s40345-016-0046-4
关键词
Mood disorders; Bipolar disorders; Depression; Thyroid peroxidase antibodies; Thyroid microsomal antibodies; Thyroglobulin antibodies; Hashimoto's thyroiditis; Hashimoto's encephalopathy; Lithium
类别
Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to play a role in specific forms of mood disorders. Potentially related forms include treatment-refractory cases, severe or atypical depression, and depression at specific phases of a woman's life (early gestation, postpartum depression, perimenopausal). With regard to bipolar disorder, studies of specific subgroups (rapid cycling, mixed, or depressive bipolar) have reported associations with thyroid antibodies. Offspring of bipolar subjects were found more vulnerable to develop thyroid antibodies independently from the vulnerability to develop psychiatric disorders. A twin study suggested thyroid antibodies among possible endophenotypes for bipolar disorder. Severe encephalopathies have been reported in association with Hashimoto's thyroiditis. Cases with pure psychiatric presentation are being reported, the antithyroid antibodies being probably markers of some other autoimmune disorders affecting the brain. Vasculitis resulting in abnormalities in cortical perfusion is one of the possible mechanisms.
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