期刊
EXPERIMENTAL GERONTOLOGY
卷 68, 期 -, 页码 3-7出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2014.09.018
关键词
Aging; Brain; Cellular senescence; Senescence associated secretory phenotype; Neurodegeneration
资金
- Ellison Senior Scholar Fellowship
- Buck Impact Circle
- NIA [PPG AG025901, R37 AG009909]
- CIRM [TG2-01155]
- American Italian Cancer Foundation
- [T32 AG000266]
Cellular senescence is a potent anti-cancermechanismthat arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of nonneuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies. (C) 2014 Elsevier Inc. All rights reserved.
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