Synthesis of 3-phosphinoylquinolines via a phosphinoylation-cyclization-aromatization process mediated by tert-butyl hydroperoxide

The first metal-free phosphinoylation- cyclization-aromatization method has been developed. The present methodology produces a series of substituted 3-phosphinoylquinolines in moderate to good yields from N-propargylanilines and H-phosphine oxides mediated by tert-butyl hydroperoxide.