期刊
AIDS
卷 32, 期 6, 页码 825-828出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0000000000001760
关键词
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资金
- Swedish Research Council [2016-03052, 2015-00174]
- Swedish Cancer Society [CAN 2014/879]
- US National Institutes of Health [R01DK108350]
- Fundacao para a Ciencia e a Tecnologia Doctoral Fellowship [SFRH/BD/85290/2012]
- Jonas Soderquist Foundation for Virology and Immunology
- Marie Sklodowska Curie Actions, Cofund [INCA 600398]
- NIAID, NIH
- National Cancer Institute, National Institutes of Health [HHSN261200800001E]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001121] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK108350] Funding Source: NIH RePORTER
Chronic HIV-1 infection is associated with lower frequencies and functional impairment ofmucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1-infected individuals on antiretroviral therapy. IL-7 led to increased relative and absolute levels of MAIT cells, and this expansion occurred primarily in the CD8(+) subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.
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