期刊
AGING-US
卷 10, 期 2, 页码 266-277出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101388
关键词
BRIP1; polymorphism; cancer risk; meta-analysis
资金
- National Natural Science Foundation of China [81471670]
- Science and Technology Project of Shaanxi Province [2017SF-172]
- Key research and development plan, Shaanxi Province, People's Republic of China [2017ZDXM-SF-066]
- International Cooperative Project of Shaanxi province, China [2016KW-008]
- Fundamental Research Funds for the Central Universities, China [2014gjhz11]
- BIKANG Funding [2017BIKANGJIJIN-020]
- Second Affiliated Hospital of Xi'an Jiaotong University for Young Scientists, China [YJ(QN)201305]
Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.
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