期刊
JOURNAL OF BONE ONCOLOGY
卷 5, 期 3, 页码 93-95出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbo.2016.02.008
关键词
RANKL; RANK; OPG; PTHrP; miRNA; Bone resorption
类别
Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells. Osteoclast-mediated bone degradation subsequently leads to the release of bone-derived factors that promote skeletal tumour growth. Osteoclasts themselves stimulate tumour growth. This Review describes the molecular mechanisms through which osteoclasts and breast cancer cells collaborate with each other, triggering the formation of osteolytic bone metastasis. (C) 2016 The Authors. Published by Elsevier GmbH.
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