期刊
CURRENT STEM CELL REPORTS
卷 2, 期 3, 页码 207-220出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s40778-016-0058-0
关键词
Injectable hydrogels; Stem cells; Regenerative medicine; Cell survival; Functional recovery
资金
- NIH [R21 EB020235-01, U19 AI116484-01, R21 EB018407-01]
- CIRM [RT307948]
- NSF [DMR 1508006]
- Geballe Laboratory for Advanced Materials (LMM)
Stem cell-based therapies are steadily gaining traction for regenerative medicine approaches to treating disease and injury throughout the body. While a significant body of work has shown success in preclinical studies, results often fail to translate in clinical settings. One potential cause is the massive transplanted cell death that occurs post-injection, preventing functional integration with host tissue. Therefore, current research is focusing on developing injectable hydrogel materials to protect cells during delivery and to stimulate endogenous regeneration through interactions of transplanted cells and host tissue. This review explores the design of targeted injectable hydrogel systems for improving the therapeutic potential of stem cells across a variety of tissue engineering applications with a focus on hydrogel materials that have progressed to the stage of preclinical testing.
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