期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 17, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms17091408
关键词
senescence; aging; senescence-associated secretory phenotype (SASP); extracellular vesicles; exosomes; ectosomes; microvesicles
资金
- Fondazione Cassa di Risparmio di Perugia [2016.0050.021]
Cell senescence is associated with the secretion of many factors, the so-called senescence-associated secretory phenotype, which may alter tissue microenvironment, stimulating the organism to clean up senescent cells and replace them with newly divided ones. Therefore, although no longer dividing, these cells are still metabolically active and influence the surrounding tissue. Much attention has been recently focused not only on soluble factors released by senescent cells, but also on extracellular vesicles as conveyors of senescence signals outside the cell. Here, we give an overview of the role of extracellular vesicles in biological processes and signaling pathways related to senescence and aging.
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