期刊
EXPERIMENTAL DERMATOLOGY
卷 24, 期 2, 页码 150-152出版社
WILEY-BLACKWELL
DOI: 10.1111/exd.12586
关键词
cyclic adenosine monophosphate; dendricity; ginsenoside F1; melanogenesis; small GTPase
类别
资金
- Interrelated Development Program of Inter-Economic Regions, Ministry for Knowledge Economy, Republic of Korea [R-0000452]
- National Research Foundation of Korea - Korean government [2010-0029233]
Ginsenoside F1 (GF1) is a metabolite produced by hydrolysis of the ginsenoside Re and Rg1 in Panax ginseng. According to various studies, high amounts of ginseng components are absorbed in the metabolized form, which are key constituents responsible for the biological effects of P.ginseng. Recently, GF1 was reported to have beneficial effects on skin. However, there has not been a sound understanding of its antimelanogenic effect and underlying molecular mechanisms. In this study, GF1 reduced -melanocyte-stimulating hormone-induced melanin secretion in B16F10 cell culture media by 60%. However, it did not suppress intracellular melanin levels, tyrosinase activity and expression. Immunofluorescence assay showed that GF1 had no effect on melanosome transport, but significantly induced dendrite retraction. Pull-down assay demonstrated that GF1 primarily modulates the Rho family GTPases resulting in dendrite retraction. Collectively, these data suggest that GF1 could act as a potent skin-whitening agent.
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