期刊
ADVANCES IN CHRONIC KIDNEY DISEASE
卷 25, 期 2, 页码 202-213出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2017.10.012
关键词
Transcriptomics; Proteomics; Metabolomics; Diabetes; Epidermal growth factor
资金
- NIDDK NIH HHS [DP3 DK094292, R24 DK082841, P30 DK081943] Funding Source: Medline
Diabetic kidney disease (DKD) has a complex and prolonged pathogenesis involving many cell types in the kidney as well as extrarenal factors. It is clinically silent for many years after the onset of diabetes and usually progresses over decades. Given this complexity, a comprehensive and unbiased molecular approach is best suited to help identify the most critical mechanisms responsible for progression of DKD and those most suited for targeted intervention. Systems biological investigations provide such an approach since they examine the entire network of molecular changes that occur in a disease process in a comprehensive way instead of focusing on a single abnormal molecule or pathway. Systems biological studies can also start with analysis of the disease in humans, not in animal or cell culture models that often poorly reproduce the changes in human DKD. Indeed, in the last decade, systems biological approaches have led to the identification of critical molecular abnormalities in DKD and have directly led to development of new biomarkers and potential treatments for DKD. (C) 2017 by the National Kidney Foundation, Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据